Amniotic band sequence
Amniotic band sequence (ABS) is a group of birth defects that result when strands of the amniotic sac detach and wrap around parts of the baby in the womb. The defects may affect the face, arms, legs, fingers, or toes.
Amniotic band syndrome; Amniotic constriction bands; Constriction band syndrome; ABS; Limb-body wall complex; Constriction rings; Body wall defect
Amniotic bands are thought to be caused by damage to a part of the placenta called the amnion (or amniotic membrane). The placenta carries blood to a baby still growing in the womb. Damage to the placenta can prevent normal growth and development.
Damage to the amnion may produce fiber-like bands that can trap or compress parts of the developing baby. These bands reduce blood supply to the areas and cause them to develop abnormally.
The severity of the deformity can vary widely, from a small dent in a toe or finger to an entire body part missing or being severely underdeveloped. Symptoms may include:
- Abnormal gap in the face (if it goes across the face, it is called a cleft)
- All or part of a finger, toe, arm or leg missing (congenital amputation)
- Defect of the abdomen or chest wall (if band is located in those areas)
- Permanent band or indentation around an arm, leg, finger, or toe
Exams and Tests
The health care provider can diagnose this condition during a physical exam. This condition is usually diagnosed at birth.
Treatment varies widely. Often, the deformity is not severe and no treatment is needed. In more serious cases, major surgery may be needed to reconstruct all or some of a body part. Some cases are so severe that they cannot be repaired.
Plans should be made for careful delivery and management of the problem after birth. The baby should be delivered in a medical center that has specialists experienced in caring for babies with this condition.
How well the infant does depends on the severity of the condition. Most cases are mild and the outlook for normal function is excellent. More severe cases have more guarded outcomes.
Complications can include complete or partial loss of function of a body part. Congenital bands affecting large parts of the body cause the most problems. Some cases are so severe that they cannot be repaired.
Crum CP, Laury AR, Hirsch MS, Quick CM, Peters WA. Amniotic bands. In: Crum CP, Laury AR, Hirsch MS, Quick CM, Peters WA. eds. Gynecologic and Obstetric Pathology. Philadelphia, PA: Elsevier; 2016:776-777.
Jain JA, Fuchs KM. Amniotic band sequence. In: Copel JA, D'Alton ME, Feltovich H, et al, eds. Obstetric Imaging: Fetal Diagnosis and Care. 2nd ed. Philadelphia, PA: Elsevier; 2018:chap 98.
Kimberly G. Lee, MD, MSc, IBCLC, Associate Professor of Pediatrics, Division of Neonatology, Medical University of South Carolina, Charleston, SC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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